The role of parkin in familial and sporadic Parkinson's disease
Identifieur interne : 001A62 ( Main/Corpus ); précédent : 001A61; suivant : 001A63The role of parkin in familial and sporadic Parkinson's disease
Auteurs : Ted M. Dawson ; Valina L. DawsonSource :
- Movement Disorders [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
Abstract
Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22798
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ISTEX:574280DDE25B1A05218AFEE387A41ECAF43B80ADLe document en format XML
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